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Protein folding is the process by which a protein structure assumes its functional shape or conformation. All protein molecules are heterogeneous unbranched chains of amino acids. By coiling and folding into a specific three-dimensional shape they are able to perform their biological function.

The reverse of this process is protein denaturation, whereby a native protein is caused to lose its functional conformation, and become an amorphous, and non-functional amino acid chain. Denatured proteins may lose their solubility, and precipitate, becoming insoluble solids. In some cases, denaturation is reversible, and proteins may refold. In many other cases, however, denaturation is irreversible.

Known facts about the process


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Proteins and Enzymes :: Biomolecules

 
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Crowdsourcing & gaming combine to help solve the puzzle of protein folding: http://bit.ly/4EZyi4 http://bit.ly/8QmL5k (video) #crowdsourcing
LucLalande (Luc Lalande) Wed, 16 Dec 2009 19:41:42 -0000
Crowdsourcing & gaming combine to help solve the puzzle of protein folding: http://bit.ly/4EZyi4 http://bit.ly/8QmL5k (video) #crowdsourcing
@hansmeier007 More interesting than pre-tertiary structure protein folding models? Are you mad? *boggles*
DaisiesAndShit (Tanya Higgins) Wed, 16 Dec 2009 18:49:20 -0000
@hansmeier007 More interesting than pre-tertiary structure protein folding models? Are you mad? *boggles*
@hansmeier007 Um... No. *grins* Otherwise known as 'hydrophobic collapse', it's one of the hypothesized globular protein folding models.
DaisiesAndShit (Tanya Higgins) Wed, 16 Dec 2009 18:19:50 -0000
@hansmeier007 Um... No. *grins* Otherwise known as 'hydrophobic collapse', it's one of the hypothesized globular protein folding models.
is reading about protein folding... Oh joy.
FabFunMel (Melanie Grigsby) Wed, 16 Dec 2009 11:22:15 -0000
is reading about protein folding... Oh joy.
Maybe it's just that I'm old, but one of the most fun video games I play is Guess The Geography on the PS3 protein folding app.
DrAbominable (Abominable DrWorkman) Wed, 16 Dec 2009 06:33:45 -0000
Maybe it's just that I'm old, but one of the most fun video games I play is Guess The Geography on the PS3 protein folding app.
@OpenCLFan you want me to help you with the classes? Can even show few nifty tricks... Protein folding and visualization is my sandbox
tuparev (Georg Tuparev) Tue, 15 Dec 2009 19:18:47 -0000
@OpenCLFan you want me to help you with the classes? Can even show few nifty tricks... Protein folding and visualization is my sandbox

 
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Folderol - An open-sourced distributed computing client for exploring the results of the Human Genome Project.
Meta Description: [ The world's largest development and download repository of Open Source code and applications ]

Predictor@home - Distributed project to predict protein folding using the BOINC (Berkeley Open Infrastructure for Network Computing) client.

500 The Blueprint Initiative - Blueprint develops, hosts and maintains public biological databases and Bioinformatics software tools such as BIND, SeqHound and Distributed Folding.

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